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and acting in concert with PD-1 and CTLA-4 as an immune-checkpoint axis whose down-regulation on tumor or autoreactive lymphocytes promotes immune evasion or autoimmune pathologies such as SLE
An important homologue of this gene is CSMD1
Gene Ontology (GO) annotations associated with this gene include RNA binding and protein kinase C binding
The gene encodes the major membrane isoform
COX2 Recombinant Rabbit mAb,PBS Only (SDT-380-259) Biosimilar Antibody and acting in concert withProduct Specification Host Rabbit Synonyms Prostaglandin G H synthase 2, Cyclooxygenase 2 (COX 2), PHS II, Prostaglandin H2 synthase 2 (PGH synthase 2; PGHS 2), Prostaglandin endoperoxide synthase 2, PTGS2 Immunogen Synthetic Peptide Location Nucleus, Membrane, Endoplasmic reticulum, Microsome Accession P35354 Clone Number SDT 380 259 Antibody Type Recombinant mAb Isotype IgG Application IHC P, ICC, IF, ICFCM Reactivity Hu Purification Protein A